GHK-Cu: Copper Peptide Research Overview
For laboratory research use only. Not for human use. Research use only.
GHK-Cu (Glycyl-L-Histidyl-L-Lysine copper complex) is a naturally occurring copper-binding tripeptide found in human plasma, saliva, and urine. It has been extensively studied in preclinical models for its apparent role in skin repair, collagen synthesis, wound healing, and anti-inflammatory activity. This overview covers the research landscape for Australian researchers.
What is GHK-Cu?
GHK-Cu is a tripeptide-copper complex consisting of glycine, histidine, and lysine bound to a copper(II) ion. It was first isolated from human plasma albumin in 1973 by Loren Pickart. Plasma concentrations of GHK-Cu are highest in young adults (approximately 200 ng/mL) and decline with age, which has prompted research into its potential role in age-related tissue changes.
GHK-Cu has been studied in both topical and systemic research models. It is not approved by the TGA as a therapeutic agent and is available in Australia for laboratory research use only.
Skin and Collagen Research
Preclinical studies have examined GHK-Cu's apparent effects on fibroblast activity, collagen and elastin synthesis, and skin repair. In vitro studies have observed apparent upregulation of collagen I, collagen III, and elastin gene expression in human fibroblast cultures treated with GHK-Cu.
A 2015 review in Biomolecules examined over 50 preclinical studies on GHK-Cu, noting consistent observations of apparent wound healing acceleration, anti-inflammatory effects, and antioxidant activity in rodent and in vitro models. The authors noted GHK-Cu's apparent ability to modulate over 4,000 human genes in microarray studies.
Anti-Ageing Research
GHK-Cu has been studied in the context of skin ageing research. Preclinical studies have examined its apparent effects on matrix metalloproteinase (MMP) activity — enzymes involved in collagen degradation — observing apparent inhibition of MMP-1 and MMP-2 in some models.
Research has also examined GHK-Cu's apparent role in stimulating glycosaminoglycan synthesis, which is involved in skin hydration and structural integrity. These findings have made GHK-Cu a subject of significant interest in dermatological and cosmetic research.
Research Supply in Australia
PeptideIQ supplies research-grade GHK-Cu in Australia at ≥98% purity, verified by third-party HPLC testing. Available in lyophilised powder form with full Certificate of Analysis. Express delivery Australia-wide.
Frequently Asked Questions
Is GHK-Cu the same as copper peptide in skincare?
GHK-Cu is the specific copper-binding tripeptide used in research and some cosmetic formulations. Research-grade GHK-Cu from PeptideIQ is supplied for laboratory research use only and is not a cosmetic product.
What purity is PeptideIQ's GHK-Cu?
PeptideIQ supplies GHK-Cu at ≥98% purity verified by third-party HPLC testing, with a full Certificate of Analysis for each batch.
Disclaimer: All products supplied by PeptideIQ are for laboratory research use only. They are not approved for human use, consumption, or therapeutic application. PeptideIQ complies with all applicable Australian regulations including the Therapeutic Goods Act 1989.