MOTS-c: Mitochondrial Peptide Research
For laboratory research use only. Not for human use. Research use only.
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondria-derived peptide encoded within the mitochondrial genome. It has been studied in preclinical models for its apparent role in metabolic regulation, insulin sensitivity, exercise performance, and longevity. This overview covers the research landscape for Australian researchers.
What is MOTS-c?
MOTS-c is a 16-amino acid peptide (MRWQEMGYIFYPRKLR) encoded within the 12S rRNA gene of the mitochondrial genome. It was first identified by Chang et al. in 2015 and represents a novel class of mitochondria-derived peptides (MDPs) that appear to function as systemic hormones.
Unlike nuclear-encoded peptides, MOTS-c is translated within the mitochondria and can translocate to the nucleus, where it appears to regulate gene expression related to metabolic homeostasis. Circulating MOTS-c levels decline with age in both rodent and human studies, which has prompted research into its potential role in age-related metabolic decline.
Metabolic Research
Preclinical studies have examined MOTS-c's apparent effects on insulin sensitivity and glucose metabolism. In rodent models of diet-induced obesity, MOTS-c administration has been associated with apparent improvements in insulin sensitivity, reduced adiposity, and increased energy expenditure.
A 2015 study in Cell Metabolism by Chang et al. demonstrated apparent prevention of diet-induced obesity and insulin resistance in mice treated with MOTS-c. The authors proposed that MOTS-c acts as a mitochondrial signal that coordinates metabolic responses to nutritional stress.
Exercise and Longevity Research
Research has examined MOTS-c's apparent role in exercise adaptation. Studies in rodent models have observed apparent increases in exercise capacity and mitochondrial biogenesis following MOTS-c administration. This has prompted investigation into MOTS-c as a potential research tool for studying exercise physiology and metabolic adaptation.
Longevity research has also examined MOTS-c, with studies in C. elegans and rodent models observing apparent lifespan extension effects. The peptide's mitochondrial origin and apparent role in metabolic regulation have made it a subject of significant interest in ageing research.
Research Supply in Australia
PeptideIQ supplies research-grade MOTS-c in Australia at ≥98% purity, verified by third-party HPLC testing. Available with full Certificate of Analysis. Express delivery Australia-wide. For laboratory research use only.
Frequently Asked Questions
What makes MOTS-c unique compared to other peptides?
MOTS-c is unique because it is encoded within the mitochondrial genome rather than the nuclear genome. It represents a novel class of mitochondria-derived peptides (MDPs) that function as systemic metabolic regulators.
Is MOTS-c available in Australia?
PeptideIQ supplies research-grade MOTS-c in Australia for laboratory research use only. It is not TGA-approved for human use.
Disclaimer: All products supplied by PeptideIQ are for laboratory research use only. They are not approved for human use, consumption, or therapeutic application. PeptideIQ complies with all applicable Australian regulations including the Therapeutic Goods Act 1989.